Background and Aims Nonalcoholic steatohepatitis is rapidly becoming the leading cause of
liver failure and indication for liver transplantation. Hepatic inflammation is a key feature of …

The ability to align individual cellular information from multiple experimental sources is
fundamental for a systems-level understanding of biological processes. However, currently …

The innate B cell (IBC) population is heterogeneous and involved in the primary immune
response. IBC functions include a high ability to produce natural antibodies with IgM isotype …

Studies performed in animal models and in humans indicate that the innate arm of the
immune system provides an essential role in the initial protection against potential insults …

The mononuclear phagocytic system consists of many cells, in particular macrophages,
scattered throughout the body. However, there is increasing evidence for the heterogeneity …

Single‐cell transcriptomic studies are identifying novel cell populations with exciting
functional roles in various in vivo contexts, but identification of succinct gene marker panels …

Increased serum levels of immunoglobulin E (IgE) is a risk factor for various diseases,
including allergy and anaphylaxis. However, the source and ontogeny of B cells producing …

Abstract “γc” cytokines are a family whose receptors share a “common-gamma-chain”
signaling moiety, and play central roles in differentiation, homeostasis, and communications …

RNA-binding proteins of the ZFP36 family are best known for inhibiting the expression of
cytokines through binding to AU-rich elements in the 3′ untranslated region and promoting …

During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that
determine their ability to exit quiescence and mount effective immune responses. Here we …