[PDF][PDF] Microbiota‐driven activation of intrahepatic B cells aggravates NASH through innate and adaptive signaling
Background and Aims Nonalcoholic steatohepatitis is rapidly becoming the leading cause of
liver failure and indication for liver transplantation. Hepatic inflammation is a key feature of …
liver failure and indication for liver transplantation. Hepatic inflammation is a key feature of …
Robust single-cell matching and multimodal analysis using shared and distinct features
The ability to align individual cellular information from multiple experimental sources is
fundamental for a systems-level understanding of biological processes. However, currently …
fundamental for a systems-level understanding of biological processes. However, currently …
Innate B cells: the archetype of protective immune cells
A Grasseau, M Boudigou, L Le Pottier, N Chriti… - Clinical reviews in …, 2020 - Springer
The innate B cell (IBC) population is heterogeneous and involved in the primary immune
response. IBC functions include a high ability to produce natural antibodies with IgM isotype …
response. IBC functions include a high ability to produce natural antibodies with IgM isotype …
The interplay between innate-like B cells and other cell types in autoimmunity
GJ Tsay, M Zouali - Frontiers in immunology, 2018 - frontiersin.org
Studies performed in animal models and in humans indicate that the innate arm of the
immune system provides an essential role in the initial protection against potential insults …
immune system provides an essential role in the initial protection against potential insults …
The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish
G Ferrero, E Gomez, S Lyer, M Rovira… - Journal of leukocyte …, 2020 - academic.oup.com
The mononuclear phagocytic system consists of many cells, in particular macrophages,
scattered throughout the body. However, there is increasing evidence for the heterogeneity …
scattered throughout the body. However, there is increasing evidence for the heterogeneity …
Combinatorial prediction of marker panels from single‐cell transcriptomic data
Single‐cell transcriptomic studies are identifying novel cell populations with exciting
functional roles in various in vivo contexts, but identification of succinct gene marker panels …
functional roles in various in vivo contexts, but identification of succinct gene marker panels …
Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival
D Kwon, ES Park, M Kim, YH Choi, M Lee… - Nature …, 2022 - nature.com
Increased serum levels of immunoglobulin E (IgE) is a risk factor for various diseases,
including allergy and anaphylaxis. However, the source and ontogeny of B cells producing …
including allergy and anaphylaxis. However, the source and ontogeny of B cells producing …
[HTML][HTML] The interweaved signatures of common-gamma-chain cytokines across immunologic lineages
Abstract “γc” cytokines are a family whose receptors share a “common-gamma-chain”
signaling moiety, and play central roles in differentiation, homeostasis, and communications …
signaling moiety, and play central roles in differentiation, homeostasis, and communications …
Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1
R Newman, H Ahlfors, A Saveliev, A Galloway… - Nature …, 2017 - nature.com
RNA-binding proteins of the ZFP36 family are best known for inhibiting the expression of
cytokines through binding to AU-rich elements in the 3′ untranslated region and promoting …
cytokines through binding to AU-rich elements in the 3′ untranslated region and promoting …
An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells
F Salerno, AJM Howden, LS Matheson… - Nature …, 2023 - nature.com
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that
determine their ability to exit quiescence and mount effective immune responses. Here we …
determine their ability to exit quiescence and mount effective immune responses. Here we …