The majority of active transport in the cell is driven by three classes of molecular motors: the
kinesin and dynein families that move toward the plus-end and minus-end of microtubules …

Two groundbreaking papers published in 1954 laid out the theory of the mechanism of
muscle contraction based on force-generating interactions between myofilaments in the …

Muscle contraction is driven by the cyclical interaction of myosin with actin, coupled with ATP
hydrolysis. Myosin attaches to actin, forming a crossbridge that produces force and …

Skeletal muscle can bear a high load at constant length, or shorten rapidly when the load is
low. This force-velocity relationship is the primary determinant of muscle performance in …

When a muscle contracts and shortens against a load, it performs work. The performance of
work is fuelled by the expenditure of metabolic energy, more properly quantified as enthalpy …

Muscle contraction is driven by the motor protein myosin II, which binds transiently to an
actin filament, generates a unitary filament displacement or 'working stroke', then detaches …

Since it was first observed, and especially so in recent years, the phenomenon of the so-
called “sticking point” in resistance training has attracted a substantial amount of sports and …

This review describes the early beginnings of X‐ray diffraction work on muscle structure and
the contraction mechanism in the MRC Unit in the Cavendish Laboratory, Cambridge, and …

Understanding of complex biological processes requires knowledge of molecular structures
and measurement of their dynamics in vivo. The collective chemomechanical action of …

A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …