Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …

The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Cell wall biosynthesis inhibitors (CBIs) have historically been one of the most effective
classes of antibiotics. They are the most extensively used class of antibiotics and their …

Abstract Perfluorooctanoic acid (PFOA), a" forever chemical", is continuously discharged
and mitigated in the environment despite its production and use being severely restricted …

Targeted covalent inhibitors have become an integral part of a number of therapeutic
protocols and are the subject of intense research. The mechanism of action of these …

The peptidoglycan sacculus is a net-like polymer that surrounds the cytoplasmic membrane
in most bacteria. It is essential to maintain the bacterial cell shape and protect from turgor …

The present study involves the synthesis of a new series of α-aminophosphonate derivatives
in good yields with a simple workup via the Kabachnik–Fields reaction using lithium …

With antibiotic resistance mechanisms increasing in diversity and spreading among
bacterial pathogens, the development of new classes of antibacterial agents against …