Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various
types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades …

Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

Renal inflammation and fibrosis are the common pathways leading to progressive chronic
kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as …

The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481,
inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling …

SARS-CoV-2 transmissibility is higher than that of other human coronaviruses; therefore, it
poses a threat to the populated communities. We investigated mutations among envelope …

Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of
leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29 heterodimer, are important …

Hematopoietic cell kinase (Hck) is a member of the Src family and is expressed in
hematopoietic cells. By regulating multiple signaling pathways, HCK can interact with …

Background Inborn errors of immunity are genetic disorders characterized by various
degrees of immune dysregulation that can manifest as immune deficiency, autoimmunity, or …

A series of pyrrolo [2, 3-d] pyrimidine derivatives were prepared and optimized for cytotoxic
activities against FLT3-ITD mutant cancer cells. Among them, compound 9u possessed …

Background Midostaurin combined with chemotherapy is currently used to treat newly
diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3) …