Chronic lymphocytic leukaemia: from genetics to treatment
F Bosch, R Dalla-Favera - Nature reviews Clinical oncology, 2019 - nature.com
Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
The complex karyotype in hematological malignancies: a comprehensive overview by the Francophone Group of Hematological Cytogenetics (GFCH)
F Nguyen-Khac, A Bidet, A Daudignon… - Leukemia, 2022 - nature.com
Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …
Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact
P Baliakas, S Jeromin, M Iskas… - Blood, The Journal …, 2019 - ashpublications.org
Recent evidence suggests that complex karyotype (CK) defined by the presence of≥ 3
chromosomal aberrations (structural and/or numerical) identified by using chromosome …
chromosomal aberrations (structural and/or numerical) identified by using chromosome …
High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations
M Fürstenau, YJ Thus, S Robrecht, CHM Mellink… - Blood, 2023 - ashpublications.org
Complex karyotypes have been associated with inferior outcomes in chronic lymphocytic
leukemia (CLL) treated with chemoimmunotherapy (CIT), whereas their prognostic impact in …
leukemia (CLL) treated with chemoimmunotherapy (CIT), whereas their prognostic impact in …
The impact of increasing karyotypic complexity and evolution on survival in patients with CLL treated with ibrutinib
AS Kittai, C Miller, D Goldstein, Y Huang… - Blood, The Journal …, 2021 - ashpublications.org
Complex karyotype, defined as≥ 3 cytogenetic abnormalities, is prognostic of survival in
patients treated with ibrutinib or venetoclax in relapsed/refractory (RR) chronic lymphocytic …
patients treated with ibrutinib or venetoclax in relapsed/refractory (RR) chronic lymphocytic …
[HTML][HTML] The complex karyotype landscape in chronic lymphocytic leukemia allows the refinement of the risk of Richter syndrome transformation
A Visentin, L Bonaldi, GM Rigolin, FR Mauro… - …, 2022 - ncbi.nlm.nih.gov
Complex karyotype (CK) at chronic lymphocytic leukemia (CLL) diagnosis is a negative
biomarker of adverse outcome. Since the impact of CK and its subtypes, namely type-2 CK …
biomarker of adverse outcome. Since the impact of CK and its subtypes, namely type-2 CK …
[HTML][HTML] Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study
AC Leeksma, P Baliakas, T Moysiadis, A Puiggros… - …, 2021 - ncbi.nlm.nih.gov
Complex karyotype identified by chromosome-banding analysis has been shown to have
prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high …
prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high …
Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression
M Quijada-Álamo, M Hernández-Sánchez… - Blood Cancer …, 2021 - nature.com
BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …
The complex karyotype and chronic lymphocytic leukemia: prognostic value and diagnostic recommendations
L Jondreville, D Krzisch, E Chapiro… - American Journal of …, 2020 - Wiley Online Library
Chromosomal abnormalities are frequently observed in patients with chronic lymphocytic
leukemia (CLL) and have prognostic value. Deletions of the short arm of chromosome 17 …
leukemia (CLL) and have prognostic value. Deletions of the short arm of chromosome 17 …
The combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia
A Visentin, L Bonaldi, GM Rigolin, FR Mauro… - British journal of …, 2019 - nature.com
Background Complex karyotype (CK) is a heterogeneous category with a negative impact in
chronic lymphocytic leukaemia (CLL). Our group has recently reported that CK patients with …
chronic lymphocytic leukaemia (CLL). Our group has recently reported that CK patients with …