Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …

Recent evidence suggests that complex karyotype (CK) defined by the presence of≥ 3
chromosomal aberrations (structural and/or numerical) identified by using chromosome …

Complex karyotypes have been associated with inferior outcomes in chronic lymphocytic
leukemia (CLL) treated with chemoimmunotherapy (CIT), whereas their prognostic impact in …

Complex karyotype, defined as≥ 3 cytogenetic abnormalities, is prognostic of survival in
patients treated with ibrutinib or venetoclax in relapsed/refractory (RR) chronic lymphocytic …

Complex karyotype (CK) at chronic lymphocytic leukemia (CLL) diagnosis is a negative
biomarker of adverse outcome. Since the impact of CK and its subtypes, namely type-2 CK …

Complex karyotype identified by chromosome-banding analysis has been shown to have
prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high …

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …

Chromosomal abnormalities are frequently observed in patients with chronic lymphocytic
leukemia (CLL) and have prognostic value. Deletions of the short arm of chromosome 17 …

Background Complex karyotype (CK) is a heterogeneous category with a negative impact in
chronic lymphocytic leukaemia (CLL). Our group has recently reported that CK patients with …