Histone modifications and cancer
JE Audia, RM Campbell - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
Epigenetics of hematopoiesis and hematological malignancies
D Hu, A Shilatifard - Genes & development, 2016 - genesdev.cshlp.org
Hematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms in
which normal hematopoiesis has gone awry and together account for∼ 10% of all new …
which normal hematopoiesis has gone awry and together account for∼ 10% of all new …
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition
During neocortical development, neural precursor cells (NPCs, or neural stem cells)
produce neurons first and astrocytes later. Although the timing of the fate switch from …
produce neurons first and astrocytes later. Although the timing of the fate switch from …
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
Abstract The Ink4a-Arf-Ink4b locus has a crucial role in both cellular senescence and
tumorigenesis. JmjC domain–containing histone demethylase 1b (Jhdm1b, also known as …
tumorigenesis. JmjC domain–containing histone demethylase 1b (Jhdm1b, also known as …
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors
M Yu, T Mazor, H Huang, HT Huang, KL Kathrein… - Molecular cell, 2012 - cell.com
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic
regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain …
regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain …
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
The Polycomb group (PcG) proteins mediate heritable silencing of developmental regulators
in metazoans, participating in one of two distinct multimeric protein complexes, the …
in metazoans, participating in one of two distinct multimeric protein complexes, the …
PRC1 fine-tunes gene repression and activation to safeguard skin development and stem cell specification
Polycomb repressive complexes (PRCs) 1 and 2 are essential chromatin regulators of cell
identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub …
identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub …
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
Abstract Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying
complex that monoubiquitinates histone H2A and is involved in maintaining the repressed …
complex that monoubiquitinates histone H2A and is involved in maintaining the repressed …
Ubiquitin‐specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
GN Maertens, S El Messaoudi‐Aubert, S Elderkin… - The EMBO …, 2010 - embopress.org
An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is
the mono‐ubiquitination of histone H2A by the combined action of the Posterior sex combs …
the mono‐ubiquitination of histone H2A by the combined action of the Posterior sex combs …
Chromatin regulatory mechanisms in pluripotency
JA Lessard, GR Crabtree - Annual review of cell and …, 2010 - annualreviews.org
Stem cells of all types are characterized by a stable, heritable state permissive of multiple
developmental pathways. The past five years have seen remarkable advances in …
developmental pathways. The past five years have seen remarkable advances in …