Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential

Q Wu, X Wang, E Nepovimova, A Miron, Q Liu… - Archives of …, 2017 - Springer
Paradoxically, trichothecenes have both immunosuppressive and immunostimulatory
effects. The underlying mechanisms have not been fully explored. Early studies show that …

Deoxynivalenol: Signaling pathways and human exposure risk assessment—An update

Z Wang, Q Wu, K Kuča, V Dohnal, Z Tian - Archives of toxicology, 2014 - Springer
Deoxynivalenol (DON) is a group B trichothecene and a common contaminant of crops
worldwide. This toxin is known to cause a spectrum of diseases in animals and humans …

Role of satiety hormones in anorexia induction by Trichothecene mycotoxins

C Terciolo, M Maresca, P Pinton, IP Oswald - Food and Chemical …, 2018 - Elsevier
The trichothecenes, produced by Fusarium, contaminate animal feed and human food in all
stages of production and lead to a large spectrum of adverse effects for animal and human …

Symptom-based drug prediction of lifestyle-related chronic diseases using unsupervised machine learning techniques

S Bhattacharjee, B Saha, S Saha - Computers in Biology and Medicine, 2024 - Elsevier
Background and objectives Lifestyle-related diseases (LSDs) impose a substantial
economic burden on patients and health care services. LSDs are chronic in nature and can …

Baicalin-copper complex modulates gut microbiota, inflammatory responses, and hormone secretion in DON-challenged piglets

A Zha, Z Cui, M Qi, S Liao, J Yin, B Tan, P Liao - Animals, 2020 - mdpi.com
Simple Summary Deoxynivalenol (DON) is the most common mycotoxin contaminant in the
agriculture industry worldwide. Copper is very efficacious in promoting growth performance …

Deoxynivalenol as potential modulator of human steroidogenesis

KA Urbanek… - Journal of Applied …, 2018 - Wiley Online Library
Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species.
Exposure to DON might cause disruptive effects such as reduced weight gain …

Dysregulation of energy balance by trichothecene mycotoxins: Mechanisms and prospects

B Lebrun, C Tardivel, B Félix, A Abysique, JD Troadec… - Neurotoxicology, 2015 - Elsevier
Trichothecenes are toxic metabolites produced by fungi that constitute a worldwide hazard
for agricultural production and both animal and human health. More than 40 countries have …

[HTML][HTML] PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

GI Lancaster, HL Kammoun, MJ Kraakman… - Nature …, 2016 - nature.com
Protein kinase R (PKR) has previously been suggested to mediate many of the deleterious
consequences of a high-fat diet (HFD). However, previous studies have observed …

Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins

L Keuter, M Fortmann, M Behrens, HU Humpf - Archives of Toxicology, 2024 - Springer
Toxic fungal secondary metabolites, referred to as mycotoxins, emerge in moldy food and
feed and constitute a potent but often underestimated health threat for humans and animals …

Behavioural and metabolomic changes from chronic dietary exposure to low-level deoxynivalenol reveal impact on mouse well-being

CK Faeste, F Pierre, L Ivanova, A Sayyari… - Archives of …, 2019 - Springer
The mycotoxin deoxynivalenol (DON) has a high global prevalence in grain-based products.
Biomarkers of exposure are detectable in most humans and farm animals. Considering the …