In this article, we review and evaluate a number of methods used in the design and analysis
of small three‐arm parallel cluster randomized trials. We conduct a simulation‐based study …

Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain
stimulations (NIBS) that has been proven to be effective in terms of significantly improving …

Background Medication safety in patients with polypharmacy at transitions of care is a focus
of the current Third WHO Global Patient Safety Challenge. Medication review and …

Background Inappropriate medication and polypharmacy increase morbidity, hospitalisation
rate, costs and mortality in multimorbid patients. At hospital discharge of elderly patients …

Background Financial incentives are often used to improve quality of care in chronic care
patients. However, the evidence concerning the effect of financial incentives is still …

Background: Cluster-randomised trials often use some form of restricted randomisation,
such as stratified-or covariate-constrained randomisation. Minimisation has the potential to …

Background The new injury severity score (NISS) is widely used within trauma outcomes
research. NISS is a composite anatomic severity score derived from the Abbreviated Injury …

Background Cluster randomised trials often randomise a small number of units, putting them
at risk of poor balance of covariates across treatment arms. Covariate constrained …

Introduction Helping smokers to quit is an important task of general practitioners (GPs).
However, achieving tobacco abstinence is difficult, and smokers who fail may still want to …

Background Tobacco abuse is a frequent issue in general practitioners'(GPs') offices, with
doctors playing a key role in promoting smoking cessation to their patients. However, not all …