Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

End-organ failure is one of the major healthcare challenges in the Western world. Yet, donor
organ shortage and the need for immunosuppression limit the impact of transplantation. The …

The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …

Retroviral overexpression of reprogramming factors (Oct4, Sox2, Klf4, c-Myc) generates
induced pluripotent stem cells (iPSCs). However, the integration of foreign DNA could …

Summary O-linked-N-acetylglucosamine (O-GlcNAc) has emerged as a critical regulator of
diverse cellular processes, but its role in embryonic stem cells (ESCs) and pluripotency has …

Over the past 20 years, stem cell technologies have become an increasingly attractive
option to investigate and treat neurodegenerative diseases. In the current review, we …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is
one of the most promising technologies in the field of regenerative medicine. The ability to …

Decellularization is the process by which cells are discharged from tissues/organs, but all of
the essential cues for cell preservation and homeostasis are retained in a three-dimensional …