CGRP and its receptors provide new insights into migraine pathophysiology

TW Ho, L Edvinsson, PJ Goadsby - Nature Reviews Neurology, 2010 - nature.com
Over the past 300 years, the migraine field has been dominated by two main theories—the
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …

Perisynaptic Schwann cells at the neuromuscular synapse: adaptable, multitasking glial cells

CP Ko, R Robitaille - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
The neuromuscular junction (NMJ) is engineered to be a highly reliable synapse to carry the
control of the motor commands of the nervous system over the muscles. Its development …

CGRP receptor antagonism and migraine

L Edvinsson, TW Ho - Neurotherapeutics, 2010 - Elsevier
Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral
nervous systems, consistent with control of vasodilatation, nociception, motor function …

Perisynaptic glia discriminate patterns of motor nerve activity and influence plasticity at the neuromuscular junction

KJ Todd, H Darabid, R Robitaille - Journal of Neuroscience, 2010 - Soc Neuroscience
In the nervous system, the induction of plasticity is coded by patterns of synaptic activity.
Glial cells are now recognized as dynamic partners in a wide variety of brain functions …

Perisynaptic Schwann Cells: Guardians of Neuromuscular Junction Integrity and Function in Health and Disease

TW Gould, CP Ko, H Willison… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
The neuromuscular junction (NMJ) is a highly reliable synapse to carry the control of the
motor commands of the nervous system over the muscles. Its development, organization …

Presynaptic membrane receptors in acetylcholine release modulation in the neuromuscular synapse

J Tomàs, MM Santafé, N Garcia… - Journal of …, 2014 - Wiley Online Library
Over the past few years, we have studied, in the mammalian neuromuscular junction (NMJ),
the local involvement in transmitter release of the presynaptic muscarinic ACh autoreceptors …

Chemosensory organs as models of neuronal synapses

S Shaham - Nature Reviews Neuroscience, 2010 - nature.com
Neuronal synapses are important microstructures that underlie complex cognitive capacities.
Recent studies, primarily in Caenorhabditis elegans and Drosophila melanogaster, have …

Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse

MM Santafe, M Priego, T Obis, N Garcia… - European Journal of …, 2015 - Wiley Online Library
Adenosine receptors (AR s) are present in the motor terminals at the mouse neuromuscular
junction. AR s and the presynaptic muscarinic acetylcholine receptors (mAChR s) share the …

Adenosine A1 and A2A receptor‐mediated modulation of acetylcholine release in the mice neuromuscular junction

N Garcia, M Priego, T Obis, MM Santafe… - European Journal of …, 2013 - Wiley Online Library
Immunocytochemistry shows that purinergic receptors (P1Rs) type A1 and A2A (A1R and A2
AR, respectively) are present in the nerve endings at the P6 and P30 Levator auris longus …

Purinergic modulation of synaptic signalling at the neuromuscular junction

KJ Todd, R Robitaille - Pflügers Archiv, 2006 - Springer
Purines have physiologically important functions throughout the nervous system. In both the
central (CNS) and peripheral nervous systems (PNS), purines in the form of adenosine …