Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in
cancer progression. The present review aimed to show the relations between Annexin A2 …

The glycolytic phenotype of the Warburg effect is associated with acidification of the tumor
microenvironment. In this review, we describe how acidification of the tumor …

p11 (S100A10, annexin II light chain, calpactin I light chain) is a multifunctional protein that
forms a heterotetrameric complex with Annexin A2, particularly at cell membranes. p11 …

Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is
often hindered by the inability to predict patient outcome. As such, the development of tools …

The generation of the serine protease plasmin is initiated by the binding of its zymogenic
precursor, plasminogen, to cell surface receptors. The proteolytic activity of plasmin …

S100A10, which is also known as p11, is located in the plasma membrane and forms a
heterotetramer with annexin A2. The heterotetramer, comprising of two subunits of annexin …

Abstract Background Genes in the Ras pathway have somatic mutations in at least 60% of
colorectal cancers. Despite activating the same pathway, the BRAF V600E mutation and the …

S100A10 is a small molecular weight protein expressed in the cytoplasm of many cells and
one of the members of the S100 protein family that binds calcium and forms the largest …

S100A10, a member of the S100 protein family, commonly forms a heterotetrameric complex
with Annexin A2. This is essential for the generation of cellular plasmin from plasminogen …