Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Objective To review the literature on the mechanism of action of onabotulinumtoxinA in
chronic migraine. Background OnabotulinumtoxinA is a chronic migraine preventive …

Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Calcitonin gene-related peptide (CGRP)-antagonizing drugs represent a major advance in
migraine treatment. However, up to 50% of patients do not benefit from monoclonal …

Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

Humans have a diverse collection of neuropeptides that can influence a multitude of
activities. There are now over 100 known neuropeptides and probably many more yet to be …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated anti-
migraine efficacy. One remaining question is where do these blockers act? We hypothesized …

Tactile and spontaneous pains are poorly managed symptoms of inflammatory and
neuropathic injury. Here, we found that transient receptor potential canonical 5 (TRPC5) is a …