Fibrosis is a hallmark of chronic disease. Although fibroblasts are involved, it is unclear to
what extent endothelial cells also might contribute. We detected increased expression of the …

BACKGROUND: Endothelial cells (ECs) are primed to respond to various signaling cues.
For example, TGF (transforming growth factor)-β has major effects on EC function and …

The aging process is a complex and multifaceted phenomenon affecting all living
organisms. It involves a gradual deterioration of tissue and cellular function, leading to a …

Simple Summary Endothelial cells constitute the inner layer of blood vessels and they are
the main constituent of the capillaries, which are the smallest blood vessels of the body that …

Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is a crucial
process altering gene expression. Musashi family of RBPs comprising Msi1 and Msi2 is …

Aging of the organism is associated diminished response to external stimuli including
weakened immune function, resulting in diseases that impair health and lifespan. Several …

Heart failure remains one of the largest clinical burdens globally, with little to no
improvement in the development of disease-eradicating therapeutics. Integrin targeting has …

Cardiovascular diseases, both congenital and acquired, are the leading cause of death
worldwide, associated with significant health consequences and economic burden. Due to …

Aims Pathological overload triggers maladaptive myocardial remodelling that leads to heart
failure. Recent studies have shown that long non-coding RNAs (lncRNAs) contribute to the …

Recent studies of cardiac translatomes have revealed widespread translation of small open
reading frames into microproteins. Once described as translational noise, these peptides are …