Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …
recent advances in cell-based models, including human-induced pluripotent stem cell …
Adapting to a new environment: postnatal maturation of the human cardiomyocyte
S Salameh, V Ogueri, NG Posnack - The Journal of Physiology, 2023 - Wiley Online Library
The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …
stimulated by the transition from the intrauterine to extrauterine environment. With birth …
Stop the beat to see the rhythm: excitation-contraction uncoupling in cardiac research
Optical mapping is an imaging technique that is extensively used in cardiovascular
research, wherein parameter-sensitive fluorescent indicators are used to study the …
research, wherein parameter-sensitive fluorescent indicators are used to study the …
Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology, as compared with bisphenol A
Bisphenol A (BPA) is a high-production volume chemical used to manufacture consumer
and medical-grade plastic products. Due to its ubiquity, the general population can incur …
and medical-grade plastic products. Due to its ubiquity, the general population can incur …
Cellular size, gap junctions, and sodium channel properties govern developmental changes in cardiac conduction
Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na+) channels
and gap junctions (GJs). We and others have recently shown that Na+ channels …
and gap junctions (GJs). We and others have recently shown that Na+ channels …
The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model
KT Haq, BL Cooper, F Berk… - American Journal of …, 2023 - journals.physiology.org
Highlighting the importance of sex as a biological variable, we recently reported sex
differences in guinea pig in vivo electrocardiogram (ECG) measurements. However …
differences in guinea pig in vivo electrocardiogram (ECG) measurements. However …
Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique
In recent decades, the scientific community has seen an increased interest in rigor and
reproducibility. In 2017, concerns about methodological thoroughness and reporting …
reproducibility. In 2017, concerns about methodological thoroughness and reporting …
Diversity of cells and signals in the cardiovascular system
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Symposium on Systems Approach to Understanding Cardiovascular Disease and …
Connecting transcriptomics with computational modeling to reveal developmental adaptations in pediatric human atrial tissue
Nearly 1% of babies are born with congenital heart disease—many of whom will require
heart surgery within the first few years of life. A detailed understanding of cardiac maturation …
heart surgery within the first few years of life. A detailed understanding of cardiac maturation …
Mechanisms underlying age-associated manifestation of cardiac sodium channel gain-of-function
Cardiac action potentials are initiated by sodium ion (Na+) influx through voltage-gated Na+
channels. Na+ channel gain-of-function (GOF) can arise in inherited conditions due to …
channels. Na+ channel gain-of-function (GOF) can arise in inherited conditions due to …