Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals

CM Ripplinger, AV Glukhov, MW Kay… - American Journal …, 2022 - journals.physiology.org
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Adapting to a new environment: postnatal maturation of the human cardiomyocyte

S Salameh, V Ogueri, NG Posnack - The Journal of Physiology, 2023 - Wiley Online Library
The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …

Stop the beat to see the rhythm: excitation-contraction uncoupling in cardiac research

LM Swift, MW Kay, CM Ripplinger… - American Journal of …, 2021 - journals.physiology.org
Optical mapping is an imaging technique that is extensively used in cardiovascular
research, wherein parameter-sensitive fluorescent indicators are used to study the …

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology, as compared with bisphenol A

TM Prudencio, LM Swift, D Guerrelli… - Toxicological …, 2021 - academic.oup.com
Bisphenol A (BPA) is a high-production volume chemical used to manufacture consumer
and medical-grade plastic products. Due to its ubiquity, the general population can incur …

Cellular size, gap junctions, and sodium channel properties govern developmental changes in cardiac conduction

MB Nowak, R Veeraraghavan, S Poelzing… - Frontiers in …, 2021 - frontiersin.org
Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na+) channels
and gap junctions (GJs). We and others have recently shown that Na+ channels …

The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model

KT Haq, BL Cooper, F Berk… - American Journal of …, 2023 - journals.physiology.org
Highlighting the importance of sex as a biological variable, we recently reported sex
differences in guinea pig in vivo electrocardiogram (ECG) measurements. However …

Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique

DR King, KM Hardin, GS Hoeker… - American Journal of …, 2022 - journals.physiology.org
In recent decades, the scientific community has seen an increased interest in rigor and
reproducibility. In 2017, concerns about methodological thoroughness and reporting …

Diversity of cells and signals in the cardiovascular system

E Grandi, MF Navedo, JJ Saucerman… - The Journal of …, 2023 - Wiley Online Library
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Connecting transcriptomics with computational modeling to reveal developmental adaptations in pediatric human atrial tissue

S Salameh, D Guerrelli, JA Miller… - American Journal …, 2024 - journals.physiology.org
Nearly 1% of babies are born with congenital heart disease—many of whom will require
heart surgery within the first few years of life. A detailed understanding of cardiac maturation …

Mechanisms underlying age-associated manifestation of cardiac sodium channel gain-of-function

MB Nowak, S Poelzing, SH Weinberg - Journal of molecular and cellular …, 2021 - Elsevier
Cardiac action potentials are initiated by sodium ion (Na+) influx through voltage-gated Na+
channels. Na+ channel gain-of-function (GOF) can arise in inherited conditions due to …