The Role of TCF7L2 in Type 2 Diabetes
L del Bosque-Plata, E Martínez-Martínez… - Diabetes, 2021 - Am Diabetes Assoc
TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …
been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that …
[HTML][HTML] A Review of the Impact of Pharmacogenetics and Metabolomics on the Efficacy of Metformin in Type 2 Diabetes
ZA Damanhouri, HM Alkreathy, FA Alharbi… - … Journal of Medical …, 2023 - ncbi.nlm.nih.gov
Metformin is the most often prescribed drug for people with type 2 diabetes (T2D). More than
120 million patients with T2D use metformin worldwide. However, monotherapy fails to …
120 million patients with T2D use metformin worldwide. However, monotherapy fails to …
Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …
[HTML][HTML] Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells
Abstract Objective Canonical Wnt/β-catenin signaling is a well-studied endogenous
regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and …
regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and …
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis
B Dong, M Hiasa, Y Higa, Y Ohnishi, I Endo… - Nature …, 2022 - nature.com
Exercise results in mechanical loading of the bone and stimulates energy expenditure in the
adipose tissue. It is therefore likely that the bone secretes factors to communicate with …
adipose tissue. It is therefore likely that the bone secretes factors to communicate with …
A PPARγ/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice
Interplay between energy-storing white adipose cells and thermogenic beige adipocytes
contributes to obesity and insulin resistance. Irrespective of specialized niche, adipocytes …
contributes to obesity and insulin resistance. Irrespective of specialized niche, adipocytes …
Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells
J Wenzel, K Rose, EB Haghighi, C Lamprecht… - Oncogene, 2020 - nature.com
The transcription factor TCF7L2 is indispensable for intestinal tissue homeostasis where it
transmits mitogenic Wnt/β-Catenin signals in stem and progenitor cells, from which intestinal …
transmits mitogenic Wnt/β-Catenin signals in stem and progenitor cells, from which intestinal …
Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link
V Ramírez, P González-Palacios, MA Baca… - Science of The Total …, 2022 - Elsevier
Current evidence highlights the importance of the genetic component in obesity and
neurodevelopmental disorders (attention-deficit hyperactivity disorder (ADHD), autism …
neurodevelopmental disorders (attention-deficit hyperactivity disorder (ADHD), autism …
Wnt signaling: from mesenchymal cell fate to lipogenesis and other mature adipocyte functions
DP Bagchi, OA MacDougald - Diabetes, 2021 - Am Diabetes Assoc
Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …
The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes
L del Bosque‐Plata… - Journal of Cellular …, 2022 - Wiley Online Library
The TCF7L2 protein is a key transcriptional effector of the Wnt/β‐catenin signaling pathway,
regulating gene expression. It was initially identified in cancer research and embryologic …
regulating gene expression. It was initially identified in cancer research and embryologic …