Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …

Tumours reprogram host physiology, metabolism and immune responses during cancer
progression. The release of soluble factors, exosomes and metabolites from tumours leads …

Background & Aims Pancreatic cancer has the highest prevalence of cancer-associated
cachexia among all cancers. ZIP4 promotes pancreatic cancer progression by regulating …

Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDA) is
characterized by immune tolerance, which enables disease to progress unabated by …

Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely activated
γδT cell population, which constituted∼ 40% of tumor-infiltrating T cells in human pancreatic …

Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In
cancer, cachexia is associated with increased morbidity and mortality and decreased …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

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Cancer cachexia is a multifactorial syndrome that is characterised by a loss of skeletal
muscle mass, is commonly associated with adipose tissue wasting and malaise, and …