[HTML][HTML] Strategies and mechanisms for endosomal escape of therapeutic nucleic acids
M Grau, E Wagner - Current Opinion in Chemical Biology, 2024 - Elsevier
Despite impressive recent establishment of therapeutic nucleic acids as drugs and vaccines,
their broader medical use is impaired by modest performance in intracellular delivery …
their broader medical use is impaired by modest performance in intracellular delivery …
[HTML][HTML] Dual Effect by Chemical Electron Transfer Enhanced siRNA Lipid Nanoparticles: Reactive Oxygen Species-Triggered Tumor Cell Killing Aggravated by Nrf2 …
Insufficient endosomal escape presents a major hurdle for successful nucleic acid therapy.
Here, for the first time, a chemical electron transfer (CET) system was integrated into small …
Here, for the first time, a chemical electron transfer (CET) system was integrated into small …
Endosomal escape of RNA therapeutics
H Du Rietz - 2024 - portal.research.lu.se
RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last
decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven …
decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven …
[PDF][PDF] Enhancing endosomal escape of siRNA through chemical electron transfer
F Zhang - 2024 - edoc.ub.uni-muenchen.de
RNA interference (RNAi) is a biological defense mechanism against exogenous gene
invasion, discovered by pioneering studies in the 1990s [1, 2]. The process involves the …
invasion, discovered by pioneering studies in the 1990s [1, 2]. The process involves the …