Actin dynamics in cell migration

M Schaks, G Giannone, K Rottner - Essays in biochemistry, 2019 - portlandpress.com
Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …

Rac1: A regulator of cell migration and a potential target for cancer therapy

N Ma, E Xu, Q Luo, G Song - Molecules, 2023 - mdpi.com
Cell migration is crucial for physiological and pathological processes such as
morphogenesis, wound repair, immune response and cancer invasion/metastasis. There are …

Super-resolution microscopy: a closer look at synaptic dysfunction in Alzheimer disease

P Padmanabhan, A Kneynsberg, J Götz - Nature Reviews …, 2021 - nature.com
The synapse has emerged as a critical neuronal structure in the degenerative process of
Alzheimer disease (AD), in which the pathogenic signals of two key players—amyloid-β (Aβ) …

Nanotube‐like processes facilitate material transfer between photoreceptors

AA Kalargyrou, M Basche, A Hare, EL West… - EMBO …, 2021 - embopress.org
Neuronal communication is typically mediated via synapses and gap junctions. New forms
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …

From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly

P Bieling, K Rottner - Current Opinion in Cell Biology, 2023 - Elsevier
Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …

Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration

A Mehidi, F Kage, Z Karatas, M Cercy, M Schaks… - Nature Cell …, 2021 - nature.com
Actin filaments generate mechanical forces that drive membrane movements during
trafficking, endocytosis and cell migration. Reciprocally, adaptations of actin networks to …

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

T Orré, A Joly, Z Karatas, B Kastberger… - Nature …, 2021 - nature.com
Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity,
migration, proliferation and differentiation. Super-resolution microscopy revealed that FAs …

Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures

S Massou, F Nunes Vicente, F Wetzel, A Mehidi… - Nature cell …, 2020 - nature.com
Detection and conversion of mechanical forces into biochemical signals controls cell
functions during physiological and pathological processes. Mechanosensing is based on …

Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion

FN Vicente, T Chen, O Rossier, G Giannone - Trends in Cell Biology, 2023 - cell.com
Detection and conversion of mechanical forces into biochemical signals is known as
mechanotransduction. From cells to tissues, mechanotransduction regulates migration …

Friction patterns guide actin network contraction

A Colin, M Orhant-Prioux, C Guérin… - Proceedings of the …, 2023 - National Acad Sciences
The shape of cells is the outcome of the balance of inner forces produced by the actomyosin
network and the resistive forces produced by cell adhesion to their environment. The specific …