Iron, myelin, and the brain: neuroimaging meets neurobiology

HE Möller, L Bossoni, JR Connor, RR Crichton… - Trends in …, 2019 - cell.com
Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await
clarification. The ability to quantify specific iron forms in the living brain would open new …

[HTML][HTML] Myelin quantification with MRI: A systematic review of accuracy and reproducibility

CWJ van der Weijden, DV García, RJH Borra… - Neuroimage, 2021 - Elsevier
Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

So you want to image myelin using MRI: an overview and practical guide for myelin water imaging

J Lee, JW Hyun, J Lee, EJ Choi… - Journal of Magnetic …, 2021 - Wiley Online Library
Myelin water imaging (MWI) is an MRI imaging biomarker for myelin. This method can
generate an in vivo whole‐brain myelin water fraction map in approximately 10 minutes. It …

Probing myelin content of the human brain with MRI: A review

GF Piredda, T Hilbert, JP Thiran… - Magnetic resonance in …, 2021 - Wiley Online Library
Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured
by myelin‐insulating sheaths surrounding axons. Human cognition, sensation, and motor …

Inferring brain tissue composition and microstructure via MR relaxometry

MD Does - NeuroImage, 2018 - Elsevier
MRI relaxometry is sensitive to a variety of tissue characteristics in a complex manner, which
makes it both attractive and challenging for characterizing tissue. This article reviews the …

Evaluation of principal component analysis image denoising on multi‐exponential MRI relaxometry

MD Does, JL Olesen, KD Harkins… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose Multi‐exponential relaxometry is a powerful tool for characterizing tissue, but
generally requires high image signal‐to‐noise ratio (SNR). This work evaluates the use of …

[HTML][HTML] Variable flip angle echo planar time-resolved imaging (vFA-EPTI) for fast high-resolution gradient echo myelin water imaging

Z Dong, F Wang, KS Chan, TG Reese, B Bilgic… - NeuroImage, 2021 - Elsevier
Myelin water imaging techniques based on multi-compartment relaxometry have been
developed as an important tool to measure myelin concentration in vivo, but are limited by …

Whole brain g-ratio mapping using myelin water imaging (MWI) and neurite orientation dispersion and density imaging (NODDI)

W Jung, J Lee, HG Shin, Y Nam, H Zhang, SH Oh… - Neuroimage, 2018 - Elsevier
MR g-ratio, which measures the ratio of the aggregate volume of axons to that of fibers in a
voxel, is a potential biomarker for white matter microstructures. In this study, a new approach …

Learning‐based motion artifact removal networks for quantitative mapping

X Xu, SVVN Kothapalli, J Liu, S Kahali… - Magnetic resonance …, 2022 - Wiley Online Library
Purpose To introduce two novel learning‐based motion artifact removal networks (LEARN)
for the estimation of quantitative motion‐and B 0‐inhomogeneity‐corrected R 2∗ maps from …

[HTML][HTML] Inconsistencies in atlas-based volumetric measures of the human nucleus basalis of Meynert: A need for high-resolution alternatives

Y Wang, M Zhan, A Roebroeck, P De Weerd… - NeuroImage, 2022 - Elsevier
The nucleus basalis of Meynert (nbM) is the major source of cortical acetylcholine (ACh) and
has been related to cognitive processes and to neurological disorders. However, spatially …