Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Ubiquitination plays a central role in the regulation of various biological functions including
immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 …

Halofuginone is an analog of febrifugine—an alkaloid originally isolated from the plant
Dichroa febrifuga. During recent years, halofuginone has attracted much attention because …

TGF-β derived from bone fuels melanoma bone metastases by inducing tumor secretion of
prometastatic factors that act on bone cells to change the skeletal microenvironment …

Background and Purpose Halofuginone is a febrifugine derivative originally isolated from
Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic, anti‐fibrotic and anti …

The Akt/mTORC1 pathway plays a central role in the activation of Warburg effect in cancer.
Here, we present for the first time that halofuginone (HF) treatment inhibits colorectal cancer …

Cancer is still considered a “hopeless case”, which seriously endangers human health.
Therefore, it is of great significance to research and develop novel anticancer drugs. Active …

Background: We recently showed that synthetic phosphoethanolamine reduces tumour
growth and inhibits lung metastasis in vivo. Here, we investigated its anti-leukaemia effects …

Reserpine is a natural indole alkaloid isolated from Rauwolfia serpentina and has potent
antioxidant, antimicrobial, and anti-mutagenic properties. Accordingly, this study aimed to …

Traditional Chinese medicine (TCM) are both historically important therapeutic agents and
important source of new drugs. Halofuginone (HF), a small molecule alkaloid derived from …