Emerging roles of 5‐lipoxygenase phosphorylation in inflammation and cell death
QY Sun, HH Zhou, XY Mao - Oxidative Medicine and Cellular …, 2019 - Wiley Online Library
5‐Lipoxygenase (ALOX5) is an iron‐containing and nonheme dioxygenase that catalyzes
the peroxidation of polyunsaturated fatty acids such as arachidonic acid. ALOX5 is the rate …
the peroxidation of polyunsaturated fatty acids such as arachidonic acid. ALOX5 is the rate …
Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I
M Sokolowska, GE Rovati, Z Diamant, E Untersmayr… - Allergy, 2021 - Wiley Online Library
Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …
Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma
F Bruno, G Spaziano, A Liparulo, F Roviezzo… - European journal of …, 2018 - Elsevier
The products of 5-lipoxygenase are synthesized and released in the airway when an
asthmatic reaction occurs. 5-lipoxygenase via arachidonic acid metabolism produces …
asthmatic reaction occurs. 5-lipoxygenase via arachidonic acid metabolism produces …
Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis
A Koeberle, O Werz - Biotechnology advances, 2018 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostanoid formation and represent
prevalent therapeutics for treatment of inflammatory disorders. However, NSAIDs are …
prevalent therapeutics for treatment of inflammatory disorders. However, NSAIDs are …
MicroRNA Monitoring in Human Alveolar Macrophages from Patients with Smoking-Related Lung Diseases: A Preliminary Study
D Mirra, R Esposito, G Spaziano, L Sportiello, F Panico… - Biomedicines, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that is
commonly considered to be a potent driver of non-small cell lung cancer (NSCLC) …
commonly considered to be a potent driver of non-small cell lung cancer (NSCLC) …
An overview of lipoxygenase inhibitors with approach of in vivo studies
A Orafaie, M Mousavian, H Orafai… - Prostaglandins & Other …, 2020 - Elsevier
Lipoxygenases (LOXs) are enzymes which found in organisms that catalyze the
peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of …
peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of …
Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX …
M Boccellino, M Donniacuo, F Bruno, B Rinaldi… - European Journal of …, 2019 - Elsevier
Stilbenes with well-known antioxidant and antiradical properties are beneficial in different
pathologies including cardiovascular diseases. The present research was performed to …
pathologies including cardiovascular diseases. The present research was performed to …
Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids
Stilbenoids represent a large group of bioactive compounds, which occur in food and
medicinal plants. Twenty-five stilbenoids were screened in vitro for their ability to inhibit COX …
medicinal plants. Twenty-five stilbenoids were screened in vitro for their ability to inhibit COX …
The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves …
FR Guimaraes, H Sales-Campos, V Nardini… - Clinical …, 2018 - Elsevier
To analyze the participation of the enzyme 5-lipoxygenase (5-LO) in skin repair, WT wounds
were compared to those in 5-LO deficient mice (5-LO−/−), which presented faster closure …
were compared to those in 5-LO deficient mice (5-LO−/−), which presented faster closure …
Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents
O Werz, J Gerstmeier, U Garscha - Expert opinion on therapeutic …, 2017 - Taylor & Francis
ABSTRACT Introduction: Leukotrienes (LTs) are lipid mediators produced from arachidonic
acid with a broad variety of bioactivities in allergy and inflammation. The biosynthesis of LTs …
acid with a broad variety of bioactivities in allergy and inflammation. The biosynthesis of LTs …