Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for
regulation of vascular development and angiogenesis. Since bone is a highly vascularized …

In addition to their conventional role as a versatile transport system, blood vessels provide
signals controlling organ development, regeneration, and stem cell behavior. In the skeletal …

Abstract Polyether-ether-ketone (PEEK) is one of the most common materials used for load-
bearing orthopaedic devices due to its radiolucency and favorable mechanical properties …

Angiogenesis is a key component of bone repair. New blood vessels bring oxygen and
nutrients to the highly metabolically active regenerating callus and serve as a route for …

Several growth factors are expressed in distinct temporal and spatial patterns during fracture
repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of …

Skeletal development and turnover occur in close spatial and temporal association with
angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen tension and …

One of the biggest challenges in regenerative medicine is promoting sufficient
vascularisation of tissue-engineered constructs. One approach to overcome this challenge is …

Hypoxia is known to act as a general stimulator of cells derived from marrow precursors. We
investigated the effect of oxygen tension on the formation and function of osteoclasts, the …

Angiogenesis is essential in bone fracture healing for restoring blood flow to the fracture site.
Vascular endothelial growth factor (VEGF) and its receptor have been implicated in this …

Pulsed electromagnetic fields (PEMF) have been shown to be clinically beneficial, but their
mechanism of action remains unclear. The present study examined the impact of PEMF on …