Animal venoms are rich natural sources of bioactive compounds, including peptide toxins
acting on the various types of ion channels, ie K+, Na+, Cl-and Ca2+. Among K+ channel …

During the last two decades since the identification and characterization of T cell potassium
channels great advances have been made in the understanding of the role of these …

Abstract Calcium (Ca 2+) signaling in T lymphocytes is essential for a variety of functions,
including the regulation of differentiation, gene transcription, and effector functions. A major …

Two major K+ channels are expressed in T cells,(i) the voltage-dependent KV 1.3 channel
and (ii) the Ca 2+-activated K+ channel KCa 3.1 (IKCa channel). Both critically influence T …

Lupus nephritis (LN) is an autoimmune disease with substantial morbidity/mortality and
limited efficacy of available therapies. Memory T (Tm) lymphocytes infiltrate LN kidneys …

Significance: Potassium channels regulate the influx and efflux of K+ ions in various cell
types that generate and propagate action potential associated with excitation, contraction …

The current concepts and practice of cancer immunotherapy evolved from classical
experiments that distinguished" self" from" non-self" and the finding that humoral immunity is …

Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response.
However, their function is attenuated in solid tumors. CD8+ T-cell effector functions, such as …

Since the discovery of the Kv1. 3 voltage-gated K+ channel in human T cells in 1984, ion
channels are considered crucial elements of the signal transduction machinery in the …

Abstract Voltage-gated Kv1. 3 and Ca2+-activated IKCa1 K+ channels play a pivotal role in
antigendependent activation and proliferation of lymphocytes. These channels primarily …