Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical
signals into biochemical responses, has focused on identification of critical …

The zebrafish is an excellent model system for studying the molecular basis of inner ear
development and function. The eggs develop ex utero and the ear is transparent for the first …

Since the publication of the human reference genome, the identities of specific genes
associated with human diseases are being discovered at a rapid rate. A central problem is …

Sensorineural hearing loss is genetically heterogeneous. Here, we report that mutations in
CIB2, which encodes a calcium-and integrin-binding protein, are associated with …

The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell
biological studies. It inhibits formin-driven actin polymerization in vitro, but not …

VEGF is the key growth factor regulating arterial morphogenesis. However, molecular events
involved in this process have not been elucidated. Synectin null mice demonstrate impaired …

Sensory neurons use specialized apical processes to perceive external stimuli and monitor
internal body conditions. The apical apparatus can include cilia, microvilli, or both, and is …

The coordinated trafficking and tethering of membrane cargo within cells relies on the
function of distinct cytoskeletal motors that are targeted to specific subcellular compartments …

The 10 different genes associated with the deaf/blind disorder, Usher syndrome, encode a
number of structurally and functionally distinct proteins, most expressed as multiple …

Unconventional myosins are multi-potent molecular motors that are assigned important roles
in fundamental cellular processes. Depending on their mechano-enzymatic properties and …