Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Manganese (Mn) is an essential trace element necessary for physiological processes that
support development, growth and neuronal function. Secondary to elevated exposure or …

Early (or preclinical) diagnosis of Parkinson's disease (PD) is crucial for its early
management as by the time manifestation of clinical symptoms occur, more than 60% of the …

Abstract Background Accurate diagnosis of Parkinson disease (PD) and other degenerative
parkinsonian syndromes is important for management and prognostic purposes. Diagnosis …

The protein alpha-synuclein (αSYN) plays a central role in synucleinopathies such as
Parkinsons's disease (PD) and multiple system atrophy (MSA). Presently, there are no …

Objective: Imaging of regional cerebral glucose metabolism with PET and striatal dopamine
D2/D3 receptors (D2R) with SPECT improves the differential diagnosis of parkinsonism. We …

Objective To characterize the expression in skin nerves of native (n‐syn) and misfolded
phosphorylated (p‐syn) α‐synucleins in pure autonomic failure (PAF) and idiopathic …

Importance Clinical case reports of parkinsonism co-occurring with hemizygous 22q11. 2
deletions and the associated multisystem syndrome, 22q11. 2 deletion syndrome (22q11 …

Early and accurate diagnosis of Parkinson's disease (PD) is important for early
management, proper prognostication and for initiating neuroprotective therapies once they …