Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and
regulatory molecules and so act as a platform for signal transduction. They float freely within …

▪ Abstract This review summarizes key aspects of tetraspanin proteins, with a focus on the
functional relevance and structural features of these proteins and how they are organized …

The adaptive immune response is initiated by the interaction of T cell antigen receptors with
major histocompatibility complex molecule-peptide complexes in the nanometer scale gap …

The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

The plasma membrane of cells is composed of lateral heterogeneities, patches and
microdomains. These membrane microdomains or lipid rafts are enriched in …

Exciting new findings have emerged about the structure, function and biochemistry of
tetraspanin proteins. Five distinct tetraspanin regions have now been delineated linking …

CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional
protein that exerts its different functions depending on cell type and intra-or extracellular …

Relatively little attention has been given to the large family of abundantly expressed
transmembrane proteins known as tetraspanins. Now, the importance of tetraspanins is …

The cells of both the adaptive and innate immune systems express a dizzying array of
receptors that transduce and integrate an enormous amount of information about the …

Translocation of conventional protein kinases C (PKCs) to the plasma membrane leads to
their specific association with transmembrane-4 superfamily (TM4SF; tetraspanin) proteins …