Interactions between a bacterial pathogen and its potentially susceptible host are initiated
with the colonization step. During respiratory/oral infection, the pathogens must compete …

Streptococcus pneumoniae is a major human pathogen responsible for the majority of
bacterial pneumonia cases as well as invasive pneumococcal diseases with high mortality …

Neutrophils, or polymorphonuclear leukocytes, comprise a crucial component of innate
immunity, controlling bacterial and fungal infection through a combination of both oxidative …

Streptococcus pneumoniae (Spn) colonizes the nasopharynx and can cause pneumonia.
From the lungs it spreads to the bloodstream and causes organ damage. We characterized …

Certain pathogens recruit host complement inhibitors such as factor H (fH) to evade the
immune system. Microbial complement inhibitor-binding molecules can be promising …

Streptococcus pneumoniae (the pneumococcus) is a major human pathogen and a leading
cause of inflammatory infections such as pneumonia and otitis media. An important …

From a common ancestor, Streptococcus pneumoniae and Streptococcus mitis evolved in
parallel into one of the most important pathogens and a mutualistic colonizer of humans …

Host innate and adaptive immunity to infection with Streptococcus pneumoniae is critically
dependent on the complement system, demonstrated by the high incidence of invasive S …

Streptococcus pneumoniae (pneumococcus) is a pathogen that causes severe local and life-
threatening invasive diseases, which are associated with high mortality rates. Pneumococci …

Pathogenic bacteria display various levels of host specificity or tropism. While many bacteria
can infect a wide range of hosts, certain bacteria have strict host selectivity for humans as …