The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

Poly (ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the
therapy of several types of cancers not responding to conventional treatments. However, de …

Cell membrane chromatography (CMC) derived from pathological tissues is ideal for
screening specific components acting on specific diseases from complex medicines owing …

The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-
threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated …

Anthracyclines remain the cornerstone of treatment in many malignancies but these agents
have a cumulative dose relationship with cardiotoxicity. Development of cardiomyopathy …

Cisplatin is a commonly used chemotherapeutic drug, the clinical use of which is limited by
the development of dose-dependent nephrotoxicity. Enhanced inflammatory response …

The NO/ONOO-cycle is a primarily local, biochemical vicious cycle mechanism, centered on
elevated peroxynitrite and oxidative stress, but also involving 10 additional elements: NF-κB …

Aims During oxidative stress mitochondria become the main source of endogenous reactive
oxygen species (ROS) production. In the present study, we aimed to clarify the effects of …