(1) Background: We proposed to review worldwide estimates of cognitive impairment
prevalence and incidence in adults older than 50 years of age living in the community.(2) …

Frailty is a common and important geriatric syndrome characterized by age-associated
declines in physiologic reserve and function across multiorgan systems, leading to …

The construct of mild cognitive impairment (MCI) has evolved over the past 10 years since
the publication of the new MCI definition at the K ey S ymposium in 2003, but the core …

Under physiological conditions, the number and function of microglia—the resident
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …

Studies supporting the notion that physical activity and exercise can help alleviate the
negative impact of age on the body and the mind abound. This literature review provides an …

The frailty syndrome has recently attracted attention of the scientific community and public
health organizations as precursor and contributor of age-related conditions (particularly …

Incidence rates of cognitive impairment and dementia are rising with the ageing population.
Meanwhile, the limited success of current treatments has led to a search for early markers of …

The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort
study of common chronic conditions of aging with an emphasis on decline in cognitive and …

Objectives There is a recent consensus proposal of “cognitive frailty” defined by the
presence of both physical frailty and cognitive impairment in the absence of dementia. The …

Frailty is a known risk factor for those aged 65 and over, and its prevalence increases with
age. Definitions of frailty vary widely, and prevalence estimates are affected by the way frailty …