The role of lipid components in lipid nanoparticles for vaccines and gene therapy
CH Albertsen, JA Kulkarni, D Witzigmann… - Advanced drug delivery …, 2022 - Elsevier
Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro® …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
[HTML][HTML] mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
SA Dilliard, Q Cheng… - Proceedings of the …, 2021 - National Acad Sciences
Lipid nanoparticles (LNPs) are a clinically mature technology for the delivery of genetic
medicines but have limited therapeutic applications due to liver accumulation. Recently, our …
medicines but have limited therapeutic applications due to liver accumulation. Recently, our …
The dawn of mRNA vaccines: The COVID-19 case
R Verbeke, I Lentacker, SC De Smedt… - Journal of Controlled …, 2021 - Elsevier
In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based
vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for …
vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for …
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines
T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …
Ongoing clinical trials of nonviral siRNA therapeutics
Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …
Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA–Lipid …
Despite the worldwide success of mRNA-LNP Covid-19 vaccines, the nanoscale structures
of these formulations are still poorly understood. To fill this gap, we used a combination of …
of these formulations are still poorly understood. To fill this gap, we used a combination of …