Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …

In 1971, Gabbiani and co-workers discovered and characterized the “modification of
fibroblasts into cells which are capable of an active spasm”(contraction) in rat wound …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The fundamental mechanisms governing the perpetuation of atrial fibrillation (AF), the most
common arrhythmia seen in clinical practice, are poorly understood, which explains in part …

Cardiac fibroblasts are the major producers of extracellular matrix (ECM) to form infarct scar.
We hypothesized that fibroblasts undergo a spectrum of phenotype states over the course of …

Accumulating evidence suggests that the mechanical and biochemical signals originating
from cell–cell adhesion are critical for stem cell lineage specification. In this review, we focus …

Fibrotic cardiac disease, a leading cause of death worldwide, manifests as substantial loss
of function following maladaptive tissue remodeling. Fibrosis can affect both the heart valves …

The ability to record and analyse electrical behaviour across the heart using optical and
electrode mapping has revolutionised cardiac research. However, wider uptake of these …

Convergence of life sciences, engineering, and basic sciences has opened new horizons for
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …

Cardiac fibroblasts (cFBs) have emerged as a heterogenous cell population. Fibroblasts are
considered the main cell source for synthesis of the extracellular matrix (ECM) and as such a …