Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in developing cardiovascular diseases such as hypertension, atrial …

Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Objective To develop recommendations for cardiovascular risk (CVR) management in gout,
vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD) …

Background Studies have suggested that evening dosing with antihypertensive therapy
might have better outcomes than morning dosing. The Treatment in Morning versus Evening …

This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

Gout is a common and treatable disease caused by the deposition of monosodium urate
crystals in articular and non-articular structures. Increased concentration of serum urate …

Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory
arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions …

Hyperuricemia is caused by reduced renal/extrarenal excretion and overproduction of uric
acid. It is affected by genetic predisposition related to uric acid transporters and by visceral …