Electrostatic interactions in protein structure, folding, binding, and condensation
Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
[HTML][HTML] The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
F Ardito, M Giuliani, D Perrone… - International …, 2017 - spandidos-publications.com
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …
[HTML][HTML] Towards a structurally resolved human protein interaction network
Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …
protein interactions. Their atomic details are critical to studying their molecular mechanisms …
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Many cellular proteins demix spontaneously from solution to form liquid condensates. These
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …
The functional landscape of the human phosphoproteome
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
PV Hornbeck, B Zhang, B Murray… - Nucleic acids …, 2015 - academic.oup.com
Abstract PhosphoSitePlus®(PSP, http://www. phosphosite. org/), a knowledgebase
dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non …
dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non …
Protein phosphorylation: a major switch mechanism for metabolic regulation
Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …
recognized as being characterized by perturbations in intracellular metabolic regulation …
[HTML][HTML] The roles of post-translational modifications in the context of protein interaction networks
Among other effects, post-translational modifications (PTMs) have been shown to exert their
function via the modulation of protein-protein interactions. For twelve different main PTM …
function via the modulation of protein-protein interactions. For twelve different main PTM …
[HTML][HTML] A million peptide motifs for the molecular biologist
A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …
Predicting protein–protein interactions from the molecular to the proteome level
Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …