Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of …

In the 100 years since sickle cell anemia (SCA) was first described in the medical literature,
studies of its molecular and pathophysiological basis have been at the vanguard of scientific …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Objective—Systemic lupus erythematosus (SLE) is associated with the premature
development of cardiovascular disease. The platelet–endothelium interaction is important in …

ABSTRACT Introduction: Sickle Cell Disease (SCD) affects 100,000 Americans and more
than 14 million people globally, mostly in economically disadvantaged populations, and …

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies
worldwide, affecting almost 400,000 newborns globally each year. It is characterized by …

It is well-established that patients with sickle cell disease (SCD) are at substantial risk of
neurological complications, including overt and silent stroke, microstructural injury, and …

While neutrophils are the main effectors of protective innate immune responses, they are
also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood …

Blood elasticity is quantified using a single compliance model by analyzing pulsatile blood
flow. However, one compliance coefficient is influenced substantially by the microfluidic …