[HTML][HTML] Current perspectives on “off-the-shelf” allogeneic NK and CAR-NK cell therapies

EL Heipertz, ER Zynda, TE Stav-Noraas… - Frontiers in …, 2021 - frontiersin.org
Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …

[HTML][HTML] Exosomes: A potential tool for immunotherapy of ovarian cancer

X Gong, H Chi, DF Strohmer, AT Teichmann… - Frontiers in …, 2023 - frontiersin.org
Ovarian cancer is a malignant tumor of the female reproductive system, with a very poor
prognosis and high mortality rates. Chemotherapy and radiotherapy are the most common …

[HTML][HTML] Allogeneic CAR T cells: an alternative to overcome challenges of CAR T cell therapy in glioblastoma

D Martínez Bedoya, V Dutoit, D Migliorini - Frontiers in immunology, 2021 - frontiersin.org
Chimeric antigen receptor (CAR) T cell therapy has emerged as one of the major
breakthroughs in cancer immunotherapy in the last decade. Outstanding results in …

CXCR4 and anti-BCMA CAR co-modified natural killer cells suppress multiple myeloma progression in a xenograft mouse model

YY Ng, Z Du, X Zhang, WJ Chng, S Wang - Cancer Gene Therapy, 2022 - nature.com
The highly restricted expression of B-cell maturation antigen (BCMA) on plasma cells makes
it an ideal target for chimeric antigen receptor (CAR) immune cell therapy against multiple …

[HTML][HTML] Current targeted therapy for metastatic colorectal cancer

T Ohishi, MK Kaneko, Y Yoshida, A Takashima… - International journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is the third most common type of cancer and the second leading
cause of cancer deaths worldwide. Surgery or surgery plus radiotherapy and/or …

[HTML][HTML] CAR-NKT cell therapy: a new promising paradigm of cancer immunotherapy

K Hadiloo, S Tahmasebi, A Esmaeilzadeh - Cancer Cell International, 2023 - Springer
Today, cancer treatment is one of the fundamental problems facing clinicians and
researchers worldwide. Efforts to find an excellent way to treat this illness continue, and new …

Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors

F Ghaedrahmati, N Esmaeil… - Cancer …, 2023 - Wiley Online Library
Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐
tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell …

Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models

S Goto, Y Sakoda, K Adachi, Y Sekido, S Yano… - Cancer Immunology …, 2021 - Springer
Chimeric antigen receptor (CAR)-T cell therapy has impressive efficacy in hematological
malignancies, but its application in solid tumors remains a challenge. Multiple hurdles …

Multiparameter longitudinal imaging of immune cell activity in chimeric antigen receptor T cell and checkpoint blockade therapies

J Xie, F El Rami, K Zhou, F Simonetta, Z Chen… - ACS Central …, 2022 - ACS Publications
Longitudinal multimodal imaging presents unique opportunities for noninvasive surveillance
and prediction of treatment response to cancer immunotherapy. In this work we first …

Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level

L Zhang, P Liu, Y Jiang, D Fan, X He, J Zhang… - European Journal of …, 2024 - Elsevier
Colorectal cancer (CRC) is trending to be a major health problem throughout the world.
Therapeutics with dual modes of action have shown latent capacity to create ideal anti-tumor …