Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …

The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in
infected patients under HAART since interruption of the treatment inevitably leads to a …

The possibility of HIV-1 eradication has been limited by the existence of latently infected
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …

Background Persistent infection in resting CD4+ T cells prevents eradication of HIV-1. Since
the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of …

Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in
antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and …

Homeostatic proliferation ensures the longevity of central memory T-cells by inducing cell
proliferation in the absence of cellular differentiation or activation. This process is governed …

HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can
halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral …

Rarely HIV type 1 establishes proviral latency within the host genome, maintained with little
or no viral gene expression. This state has been quantitated in peripheral blood and …

Combination antiretroviral therapy (ART) can suppress plasma HIV to undetectable levels,
allowing HIV-infected individuals who are treated early a nearly normal life span. Despite …

The introduction of highly active antiretroviral therapy (HAART) in 1996 has transformed a
lethal disease to a chronic pathology with a dramatic decrease in mortality and morbidity of …