Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …

Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic
innervation in the cerebral cortex of patients with Alzheimer's disease is an early pathogenic …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens (Apostolova …

Highlights•Neurotrophins have been linked to several disorders, including AD and
depression.•Complex biology has led to difficulties in identifying suitable drug …

Neurodegenerative diseases are a major public health problem worldwide with a wide
spectrum of symptoms and physiological effects. It has been long reported that the …

Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …