Forkhead box (FOX) O proteins are transcription factors (TFs) with four members in
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …

Advancements in longevity research have provided insights into the impact of cardiac aging
on the structural and functional aspects of the heart. Notable changes include the gradual …

Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle
wasting in mammals. However, the molecular events that mediate glucocorticoid-induced …

Brain renin‐angiotensin (Ang) system (RAS) is implicated in neuroinflammation, a major
characteristic of aging process. Angiotensin (Ang) II, produced by angiotensin‐converting …

Cardiac hypertrophy and its resultant heart failure are among the most common causes of
mortality, worldwide. Long noncoding RNAs (lncRNAs) are involved in diverse biological …

Impaired autophagic flux induces aging-related ischemia vulnerability, which is the hallmark
pathology in cardiac aging. Our previous work has confirmed that the accumulation of …

Transmembrane proteins (TMEMs) are integral proteins that span biological membranes.
TMEMs function as cellular membrane gates by modifying their conformation to control the …

Left ventricular (LV) mass loss is prevalent in doxorubicin (DOX)-induced cardiotoxicity and
is responsible for the progressive decline of cardiac function. Comparing with the well …

FoxOs and their post-translational modification by phosphorylation, acetylation, and
methylation can affect epigenetic modifications and promote the expression of downstream …

Objective: Chronic stimulation of peritoneal dialysis (PD) fluid leads to the epithelial-
mesenchymal transformation (EMT) of mesothelial cells, peritoneal fibrosis (PF), and …