Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …

In the past 20 years, our understanding of the pathophysiology of depression has evolved
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …

α5 subunit containing GABA type A receptors (GABAARs) have long been an enigmatic
receptor subtype of interest due to their specific brain distribution, unusual surface …

Dendrite-targeting GABAergic interneurons powerfully control postsynaptic integration,
synaptic plasticity, and learning. However, the mechanisms underlying the efficient …

Autism spectrum disorders (ASD) are complex conditions that stem from a combination of
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …

The brain has a remarkable but underappreciated capacity to limit memory formation and
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …

In rodent models of Autism Spectrum Disorders (ASD), the study of ultrasonic vocalizations
has provided the unique opportunity to evaluate social communication and interaction in …

Background Perioperative neurocognitive disorder (PND) is a long-term postoperative
complication in elderly surgical patients. The underlying mechanism of PND is unclear, and …

Mitochondria influence cellular function through both cell-autonomous and non-cell
autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we …

We performed next generation sequencing on 1696 patients with epilepsy and intellectual
disability using a gene panel with 480 epilepsy-related genes including all GABAA receptor …