Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …

S-adenosylmethionine (SAM) is the methyl donor for biological methylation modifications
that regulate protein and nucleic acid functions. Here, we show that methylation of a …

Over the last decade, advances in genetics, neuroimaging and EEG have enabled the
aetiology of epilepsy to be identified earlier in the disease course than ever before. At the …

Over the last decade, there has been increasing evidence that hyperactivation of the
mechanistic target of rapamycin (mTOR) pathway is a hallmark of malformations of cortical …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Abstract DEP-domain containing 5 (DEPDC5), encoding a repressor of the mechanistic
target of rapamycin complex 1 (mTORC1) signaling pathway, has recently emerged as a …

Advancements in metabolomic and genomic research tools are revealing new insights into
how metabolic networks can influence skeletal muscle fiber composition. In this mini-review …

The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-
binding protein called FUS (fused in sarcoma) has been implicated in several aspects of …

Focal epilepsies, where seizures initiate in spatially limited networks, are the most frequent
epilepsy type, accounting for two-thirds of patients. Focal epilepsies have long been thought …