Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Although it can be controlled locally, half of the patients still develop metastases. To …

Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are
the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or …

Purpose: The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid
acquisition of resistance. This study has used multiomics approaches and drug screens to …

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal
melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for …

Simple Summary Chemotherapy and immunotherapy are both used to treat malignancies.
The immunotherapy of cancer often involves T cells, which recognise the antigens …

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults.
Important cytogenetic and genetic risk factors for the development of UM include …

Simple Summary Uveal melanoma (UM) is the most common adult eye cancer. UM
originates in the iris, ciliary body or choroid (collectively known as the uvea), in the middle …

Background/Aim: There is a strong association between malignancy and histone
deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as …