The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

With an estimated 9.4 million new cases globally, tuberculosis (TB) continues to be a major
public health concern. Eighty percent of all cases worldwide occur in 22 high-burden, mainly …

A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …

Neutrophils represent the main infected cell population in the lungs of active tuberculosis
patients. Efficient removal of infected and dying neutrophils is required to protect the …

To investigate the respective contributions of TLR versus IL-1R mediated signals in MyD88
dependent control of Mycobacterium tuberculosis, we compared the outcome of M …

Cells of the innate immune system produce cytokines and lipid mediators that strongly
influence the outcome of mycobacterial infection. In the case of Mycobacterium tuberculosis …

The programmed death-1 (PD-1) costimulatory receptor inhibits T and B cell responses and
plays a crucial role in peripheral tolerance. PD-1 has recently been shown to inhibit T cell …

Tuberculosis (TB) still poses a profound burden on global health, owing to significant
morbidity and mortality worldwide. Although a fully functional immune system is essential for …

Mycobacterium tuberculosis is a hard-to-eradicate intracellular pathogen that infects one-
third of the global population. It can live within macrophages owning to its ability to arrest …