Central mechanisms for thermoregulation

SF Morrison, K Nakamura - Annual review of physiology, 2019 - annualreviews.org
Maintenance of a homeostatic body core temperature is a critical brain function
accomplished by a central neural network. This orchestrates a complex behavioral and …

Embracing diversity in the 5-HT neuronal system

BW Okaty, KG Commons, SM Dymecki - Nature Reviews Neuroscience, 2019 - nature.com
Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu… - Nature, 2016 - nature.com
Brown and beige adipose tissues can dissipate chemical energy as heat through
thermogenic respiration, which requires uncoupling protein 1 (UCP1),. Thermogenesis from …

Neural control of breathing and CO2 homeostasis

PG Guyenet, DA Bayliss - Neuron, 2015 - cell.com
Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

JD Crane, R Palanivel, EP Mottillo, AL Bujak, H Wang… - Nature medicine, 2015 - nature.com
Abstract Mitochondrial uncoupling protein 1 (UCP1) is enriched within interscapular brown
adipose tissue (iBAT) and beige (also known as brite) adipose tissue,, but its thermogenic …

A hypothalamomedullary network for physiological responses to environmental stresses

K Nakamura, Y Nakamura, N Kataoka - Nature reviews neuroscience, 2022 - nature.com
Various environmental stressors, such as extreme temperatures (hot and cold), pathogens,
predators and insufficient food, can threaten life. Remarkable progress has recently been …

Infrared thermography: A non-invasive window into thermal physiology

GJ Tattersall - Comparative Biochemistry and Physiology Part A …, 2016 - Elsevier
Infrared thermography is a non-invasive technique that measures mid to long-wave infrared
radiation emanating from all objects and converts this to temperature. As an imaging …

γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

B Hu, C Jin, X Zeng, JM Resch, MP Jedrychowski… - Nature, 2020 - nature.com
The sympathetic nervous system innervates peripheral organs to regulate their function and
maintain homeostasis, whereas target cells also produce neurotrophic factors to promote …

The expanded biology of serotonin

M Berger, JA Gray, BL Roth - Annual review of medicine, 2009 - annualreviews.org
Serotonin is perhaps best known as a neurotransmitter that modulates neural activity and a
wide range of neuropsychological processes, and drugs that target serotonin receptors are …

Central neural regulation of brown adipose tissue thermogenesis and energy expenditure

SF Morrison, CJ Madden, D Tupone - Cell metabolism, 2014 - cell.com
Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic
function of brown adipose tissue (BAT) and contributes to the maintenance of body …