Aurora kinase belongs to serine/threonine kinase family which controls cell division.
Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer …

This review summarizes recent literature (2000–2015) on the synthesis and pharmaceutical
properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring …

Here, we describe the identification of a clinical candidate via structure-based optimization
of a ligand efficient pyrazole-benzimidazole fragment. Aurora kinases play a key role in the …

The Aurora kinases have been the subject of considerable interest as targets for the
development of new anticancer agents. While evidence suggests inhibition of Aurora B …

With the rise of artificial intelligence (AI) in drug discovery, de novo molecular generation
provides new ways to explore chemical space. However, because de novo molecular …

The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective
inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are …

The purine ring is the most ubiquitous nitrogen-containing heterocycle in nature, 1 since,
besides the numerous purine derivatives found in various marine organisms and plants, it is …

Pyrroles and pyrrolo [2, 3-d] pyrimidines were reported to act as potent anticancer agents, in
this work, a series of novel 2-substituted-3-cyano-4-phenyl-pyrrole 5, 6, 11–18, and 5-phenyl …

Pyrazole, as a small molecule, was discovered for higher cytotoxicity and affinity towards
Aurora-A kinase. Based on these facts, a novel pyrazole substituted at the 4 th position was …

Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines,
exerting pharmacological potential in different aspects. They are known to play a crucial role …