Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from
regenerating in the adult central nervous system (CNS). Here we show how the two aspects …

Many tissues harbor quiescent stem cells that are activated upon injury, subsequently
proliferating and differentiating to repair tissue damage. Mechanisms by which stem cells …

During development of the central nervous system (CNS), neurons polarize and rapidly
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …

Axons differ in their growth potential: whereas during development, axons rapidly grow to
their targets, in the adult mammalian, CNS axons have lost their ability to grow and therefore …

Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …

Cortical projection neurons polarize and form an axon while migrating radially. Even though
these dynamic processes are closely interwoven, they are regulated separately—the …

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Axon growth enables the rapid wiring of the central nervous system. Understanding this
process is a prerequisite to retriggering it under pathological conditions, such as a spinal …