Glycogen metabolism has important implications for the functioning of the brain, especially
the cooperation between astrocytes and neurons. According to various research data, in a …

Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Understanding brain energy metabolism—neuroenergetics—is becoming increasingly
important as it can be identified repeatedly as the source of neurological perturbations …

Monocarboxylate transporters (MCTs) are proton‐linked membrane carriers involved in the
transport of monocarboxylates such as lactate, pyruvate, as well as ketone bodies. They …

Recent in vitro studies suggest that lactate, rather than glucose, may be the preferred fuel for
neuronal metabolism. The authors examined the effect of lactate on global brain glucose …

The authors investigated concomitant lactate and glucose metabolism in primary neuronal
cultures using 13C-and 1H-NMR spectroscopy. Neurons were incubated in a medium …

Background Cerebral glucose hypometabolism is consistently observed in individuals with
Alzheimer's disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of …

Glucose had long been thought to fuel oxidative metabolism in active neurons until the
recently proposed astrocyte-neuron lactate shuttle hypothesis (ANLSH) challenged this …

Research over the past two decades has renewed the interest in lactate, no longer as a
useless end product of anaerobic glycolysis in brain (and other tissues), but as an oxidative …