Hyperinsulinaemia/euglycaemia therapy (HIET) consists of the infusion of high-dose regular
insulin (usually 0.5 to 1 IU/kg per hour) combined with glucose to maintain euglycaemia …

Diuretics (thiazides, loop diuretics) are established as treatments of common diseases:
arterial hypertension, heart failure, and renal disease. In aging societies, their prevalence …

Aims/hypothesis Our aim was to evaluate the safety and efficacy of a planned therapeutic
withdrawal of all antihypertensive and diuretic medications, on commencing a formula low …

Aims/hypothesis Diabetes and hyperlipidaemia are common comorbidities in people with
hypertension. Despite similar protective effects on CVD, different classes of antihypertensive …

Observational studies have shown that elevated systolic blood pressure (SBP) is associated
with future onset of type 2 diabetes, but whether this association is causal is not known. We …

Ivabradine is a specific heart rate-lowering antianginal agent that was evaluated in a clinical
development program involving approximately 3,000 patients with stable coronary artery …

Background Observational studies have investigated the associations between
antihypertensive drugs and fracture risk as well as bone mineral density (BMD), but yielding …

A disturbance of glucose homeostasis leading to type 2 diabetes mellitus (T2DM) is one of
the severe side effects that may occur during a prolonged use of many drugs currently …

Recently updated clinical guidelines have highlighted the gaps in our understanding and
management of pediatric hypertension. With increased recognition and diagnosis of …

Abstract Aims/Introduction Hypertension is one of the most significant risk factors for
diabetes. The present study aimed to investigate the associations of lipid profiles, including …