Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …

Serine has been recently identified as an essential metabolite for oncogenesis, progression,
and adaptive immunity. Influenced by many physiologic or tumor environmental factors, the …

Background One-third of cancers activate endogenous synthesis of serine/glycine, and can
become addicted to this pathway to sustain proliferation and survival. Mechanisms driving …

Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient
supply during fasting and other stresses. These pathways are regulated locally in tissues …

The accumulation of atypical, cytotoxic 1-deoxysphingolipids (1-dSLs) has been linked to
retinal diseases such as diabetic retinopathy and Macular Telangiectasia Type 2. However …

Sphingolipids (SLs) constitute a discrete subdomain of metabolism, and they display both
structural and signaling functions. Accumulating evidence also points to intimate …

Fatty acid omega hydroxylase P450s consist of enzymes that hydroxylate various chain-
length saturated and unsaturated fatty acids (FAs) and bioactive eicosanoid lipids. The …

The small molecule citrate is a key molecule that is synthesized de novo and involved in
diverse biochemical pathways influencing cell metabolism and function. Citrate is highly …

Objectives The non-essential amino acids serine, glycine, and alanine, as well as diverse
sphingolipid species, are implicated in inherited neuro-retinal disorders and are …

Motor neuron diseases and peripheral neuropathies are heterogeneous groups of
neurodegenerative disorders that manifest with distinct symptoms due to progressive …