Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …

Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone
proteins that play a critical role in mitigating and preventing protein aggregation under stress …

Mammalian small heat-shock proteins (sHSPs) are molecular chaperones that form
polydisperse and dynamic complexes with target proteins, serving as a first line of defense …

Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational
and functional integrity of the proteome and involves an integrated network of cellular …

The aggregation of α-synuclein (α-syn) into amyloid fibrils is associated with
neurodegenerative diseases, collectively referred to as the α-synucleinopathies. In vivo …

From transcription, to transport, storage, and translation, RNA depends on association with
different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and …

Cellular protein homeostasis (proteostasis) maintains the integrity of the proteome and
includes protein synthesis, folding, oligomerization, and turnover; chaperone proteins assist …

Neurodegenerative diseases are a group of diseases with several neuropathological
symptoms. Degenerative nerve diseases can be serious or life‐threatening. Because of the …

The accumulation of protein aggregates containing amyloid fibrils, with α-synuclein being
the main component, is a pathological hallmark of Parkinson's disease (PD). Molecules …