Microbiota-brain interactions: Moving toward mechanisms in model organisms

J Nagpal, JF Cryan - Neuron, 2021 - cell.com
Changes in the microbiota are associated with alterations in nervous system structure-
function and behavior and have been implicated in the etiology of neuropsychiatric and …

Chemosensory signal transduction in Caenorhabditis elegans

DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Glial KCNQ K+ channels control neuronal output by regulating GABA release from glia in C. elegans

B Graziano, L Wang, OR White, DH Kaplan… - Neuron, 2024 - cell.com
KCNQs are voltage-gated K+ channels that control neuronal excitability and are mutated in
epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in …

Pathogenic bacteria modulate pheromone response to promote mating

T Wu, M Ge, M Wu, F Duan, J Liang, M Chen… - Nature, 2023 - nature.com
Pathogens generate ubiquitous selective pressures and host–pathogen interactions alter
social behaviours in many animals,,–. However, very little is known about the neuronal …

Search performance and octopamine neuronal signaling mediate parasitoid induced changes in Drosophila oviposition behavior

L Pang, Z Liu, J Chen, Z Dong, S Zhou, Q Zhang… - Nature …, 2022 - nature.com
Making the appropriate responses to predation risk is essential for the survival of an
organism; however, the underlying mechanisms are still largely unknown. Here, we find that …

A glial ClC Cl− channel mediates nose touch responses in C. elegans

J Fernandez-Abascal, CK Johnson, B Graziano… - Neuron, 2022 - cell.com
In touch receptors, glia and accessory cells play a key role in mechanosensation. However,
the mechanisms underlying such regulation are poorly understood. We show, for the first …

Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

RL Hong, M Riebesell, DJ Bumbarger, SJ Cook… - Elife, 2019 - elifesciences.org
The nematodes C. elegans and P. pacificus populate diverse habitats and display distinct
patterns of behavior. To understand how their nervous systems have diverged, we …

1‐Undecene from Pseudomonas aeruginosa is an olfactory signal for flight‐or‐fight response in Caenorhabditis elegans

D Prakash, A Ms, B Radhika, R Venkatesan… - The EMBO …, 2021 - embopress.org
Animals possess conserved mechanisms to detect pathogens and to improve survival in
their presence by altering their own behavior and physiology. Here, we utilize …

A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission

YC Huang, J Luo, W Huang, CM Baker, MA Gomes… - Current Biology, 2023 - cell.com
Animals generate a wide range of highly coordinated motor outputs, which allows them to
execute purposeful behaviors. Individual neurons in the circuits that generate behaviors …

Improving Transgenesis Efficiency and CRISPR-Associated Tools Through Codon Optimization and Native Intron Addition in Pristionchus Nematodes

Z Han, WS Lo, JW Lightfoot, H Witte, S Sun… - Genetics, 2020 - academic.oup.com
A lack of appropriate molecular tools is one obstacle that prevents in-depth mechanistic
studies in many organisms. Transgenesis, clustered regularly interspaced short palindromic …